Codeina gocce e Codeina sciroppo (Paracodina® gocce e Paracodina® sciroppo) sono formulazioni orali dall'azione sedativa contro la tosse secca. In queste forme Codeina farmaco viene somministrata come diidrocodeina, che riduce la frequenza e l'intensità della tosse.
benzhydrocodone/acetaminophen and codeine the two increase sedation. Steer clear of or Use Alternate Drug. Limit use to sufferers for whom option therapy alternatives are insufficient
clomipramine decreases outcomes of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Prevents conversion of codeine to its active metabolite morphine.
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abiraterone raises levels of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Watch. Avoid coadministration of abiraterone with substrates of CYP2D6. If alternate therapy can't be utilized, physical exercise warning and consider a dose reduction of the CYP2D6 substrate.
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Gli oppioidi agiscono legandosi agli specifici recettori (recettori degli oppioidi), che si trovano principalmente nel sistema nervoso centrale e periferico e nel tratto gastrointestinale.